Bind and elute Ion Exchange (IX) chromatography systems based on the Simulated Moving Bed (SMB) principle has opened a huge field of new applications for adsorption technologies. It has resulted in gradual increase in number of valuable products being purified using IX-SMB systems.
The innovatinve XPure Systems developed at Xendo combine the traditional SMB advantage of reduced consumption of process fluids with an enhanced process flexibility, which results in higher separation efficiency and improved product titers.
We have the experience and capacity to design and build custom-made XPure continuous chromatography systems. Being part of a quality and progress-driven international organisation, we listen, understand and deliver solutions to out customer's demands.
Type of Collaboration:Fee paying basisFunded collaborative projectJoint venturesNegotiable
What "non-technical" services relevant to scale-up does your organisation offer?:Process ModellingTechnoeconomic Assessment
Expanded Bed Adsorption (XPure-E)
Biomass - any
Semi Pilot, Pilot, Demonstration
Additional Technical Information:
EBA chromatography effectively addresses the critical challenges of packed bed chromatography. It reduces e.g. clarification operations prior to the columns resulting in lower costs and improved yield. Minimal back pressure enables to achieve optimal scale of operation and productivity. The XPure-E system has been designed and built to perform EBA chromatography operation in a smooth and controlled fashion enabling:
Process development with enhanced scalability and operability
Handling viscous and turbid feed streams which are difficult to process through membranes or packed beds
Removal of clarifications steps prior to adsorption
5-15 % increase in product yield
2-4 x increase in productivity
10-20 % reduction in waste
In-situ product removal and cell recycling (fermentation based streams)